Systematic prediction of control proteins and their DNA binding sites.
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ABSTRACT:
SUBMITTER: Sorokin V
PROVIDER: S-EPMC2632904 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Systematic prediction of control proteins and their DNA binding sites.
Sorokin Valeriy V Severinov Konstantin K Gelfand Mikhail S MS
Nucleic acids research 20081204 2
We present here the results of a systematic bioinformatics analysis of control (C) proteins, a class of DNA-binding regulators that control time-delayed transcription of their own genes as well as restriction endonuclease genes in many type II restriction-modification systems. More than 290 C protein homologs were identified and DNA-binding sites for approximately 70% of new and previously known C proteins were predicted by a combination of phylogenetic footprinting and motif searches in DNA ups ...[more]
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