Using electrostatic potentials to predict DNA-binding sites on DNA-binding proteins.
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ABSTRACT:
SUBMITTER: Jones S
PROVIDER: S-EPMC291864 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
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Using electrostatic potentials to predict DNA-binding sites on DNA-binding proteins.
Jones Susan S Shanahan Hugh P HP Berman Helen M HM Thornton Janet M JM
Nucleic acids research 20031201 24
A method to detect DNA-binding sites on the surface of a protein structure is important for functional annotation. This work describes the analysis of residue patches on the surface of DNA-binding proteins and the development of a method of predicting DNA-binding sites using a single feature of these surface patches. Surface patches and the DNA-binding sites were initially analysed for accessibility, electrostatic potential, residue propensity, hydrophobicity and residue conservation. From this, ...[more]
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