Ontology highlight
ABSTRACT:
SUBMITTER: Brar GA
PROVIDER: S-EPMC2633386 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Brar Gloria A GA Hochwagen Andreas A Ee Ly-sha S LS Amon Angelika A
Molecular biology of the cell 20081210 3
Sister chromatid cohesion, mediated by cohesin complexes, is laid down during DNA replication and is essential for the accurate segregation of chromosomes. Previous studies indicated that, in addition to their cohesion function, cohesins are essential for completion of recombination, pairing, meiotic chromosome axis formation, and assembly of the synaptonemal complex (SC). Using mutants in the cohesin subunit Rec8, in which phosphorylated residues were mutated to alanines, we show that cohesin p ...[more]