Ontology highlight
ABSTRACT:
SUBMITTER: Kojic A
PROVIDER: S-EPMC6122591 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Kojic Aleksandar A Cuadrado Ana A De Koninck Magali M Giménez-Llorente Daniel D Rodríguez-Corsino Miriam M Gómez-López Gonzalo G Le Dily François F Marti-Renom Marc A MA Losada Ana A
Nature structural & molecular biology 20180604 6
Two variant cohesin complexes containing SMC1, SMC3, RAD21 and either SA1 (also known as STAG1) or SA2 (also known as STAG2) are present in all cell types. We report here their genomic distribution and specific contributions to genome organization in human cells. Although both variants are found at CCCTC-binding factor (CTCF) sites, a distinct population of the SA2-containing cohesin complexes (hereafter referred to as cohesin-SA2) localize to enhancers lacking CTCF, are linked to tissue-specifi ...[more]