Ontology highlight
ABSTRACT:
SUBMITTER: Di Lella S
PROVIDER: S-EPMC2633424 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Biochemistry 20090201 4
Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, binds specifically to poly-N-acetyllactosamine-enriched glycoconjugates. Through interactions with these glycoconjugates, this protein modulates inflammatory responses and contributes to tumor progression and immune cell homeostasis. The carbohydrate recognition domain includes the single protein tryptophan (Trp68). UV resonance Raman spectroscopy and molecular dynamic simulation were used to examine th ...[more]