Ontology highlight
ABSTRACT:
SUBMITTER: Park IH
PROVIDER: S-EPMC2633781 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Park In-Hyun IH Arora Natasha N Huo Hongguang H Maherali Nimet N Ahfeldt Tim T Shimamura Akiko A Lensch M William MW Cowan Chad C Hochedlinger Konrad K Daley George Q GQ
Cell 20080807 5
Tissue culture of immortal cell strains from diseased patients is an invaluable resource for medical research but is largely limited to tumor cell lines or transformed derivatives of native tissues. Here we describe the generation of induced pluripotent stem (iPS) cells from patients with a variety of genetic diseases with either Mendelian or complex inheritance; these diseases include adenosine deaminase deficiency-related severe combined immunodeficiency (ADA-SCID), Shwachman-Bodian-Diamond sy ...[more]