Ontology highlight
ABSTRACT:
SUBMITTER: Borde V
PROVIDER: S-EPMC2634730 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Borde Valérie V Robine Nicolas N Lin Waka W Bonfils Sandrine S Géli Vincent V Nicolas Alain A
The EMBO journal 20081211 2
The function of histone modifications in initiating and regulating the chromosomal events of the meiotic prophase remains poorly understood. In Saccharomyces cerevisiae, we examined the genome-wide localization of histone H3 lysine 4 trimethylation (H3K4me3) along meiosis and its relationship to gene expression and position of the programmed double-strand breaks (DSBs) that initiate interhomologue recombination, essential to yield viable haploid gametes. We find that the level of H3K4me3 is cons ...[more]