Ontology highlight
ABSTRACT:
SUBMITTER: Ellis JM
PROVIDER: S-EPMC2634855 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20081015 22
A new synthesis of 3,3'-bioxindoles is reported that is well suited for the preparation of unsymmetrical structures. In the key step, 3-hydroxy-3,3'-bioxindoles are constructed by Mukaiyama aldol reaction of 2-siloxyindoles with isatins. These tertiary carbinols are formed in high diastereoselectivities, with substitution at various positions of the isatin and the 2-siloxyindole being tolerated. ...[more]