Cytokine-induced signaling networks prioritize dynamic range over signal strength.

ABSTRACT: Signaling networks respond to diverse stimuli, but how the state of the signaling network is relayed to downstream cellular responses is unclear. We modeled how incremental activation of signaling molecules is transmitted to control apoptosis as a function of signal strength and dynamic range. A linear relationship between signal input and response output, with the dynamic range of signaling molecules uniformly distributed across activation states, most accurately predicted cellular responses. When nonlinearized signals with compressed dynamic range relay network activation to apoptosis, we observe catastrophic, stimulus-specific prediction failures. We develop a general computational technique, "model-breakpoint analysis," to analyze the mechanism of these failures, identifying new time-

SUBMITTER: Janes KA 

PROVIDER: S-EPMC2635014 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature