Signal Transduction at the Single-Cell Level: Approaches to Study the Dynamic Nature of Signaling Networks.
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ABSTRACT:
SUBMITTER: Handly LN
PROVIDER: S-EPMC5023475 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Signal Transduction at the Single-Cell Level: Approaches to Study the Dynamic Nature of Signaling Networks.
Handly L Naomi LN Yao Jason J Wollman Roy R
Journal of molecular biology 20160716 19
Signal transduction, or how cells interpret and react to external events, is a fundamental aspect of cellular function. Traditional study of signal transduction pathways involves mapping cellular signaling pathways at the population level. However, population-averaged readouts do not adequately illuminate the complex dynamics and heterogeneous responses found at the single-cell level. Recent technological advances that observe cellular response, computationally model signaling pathways, and expe ...[more]
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