Ontology highlight
ABSTRACT:
SUBMITTER: Favre D
PROVIDER: S-EPMC2635016 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
PLoS pathogens 20090213 2
Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non-pathogenic infection in African green monkeys (AGMs). SIVagm-infected PTs, but not SIVagm-infected AGMs, rapidly developed systemic immune activation, marked and selective depletion of IL-17-secreting (Th17) cells, and loss of the balance between Th ...[more]