Ontology highlight
ABSTRACT:
SUBMITTER: Solinas R
PROVIDER: S-EPMC2635021 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20090113 1
The imidazole-4,5-dicarboxylic acid scaffold is readily derivatized with amino acid esters to afford symmetrically- and dissymmetrically-disubstituted imidazole-4,5-dicarboxamides with intramolecularly hydrogen bonded conformations that predispose the presentation of amino acid pharmacophores. In this work, a total of 45 imidazole-4,5-dicarboxamides bearing amino acid esters were prepared by parallel synthesis. The library members were purified by column chromatography on silica gel and the puri ...[more]