Ontology highlight
ABSTRACT:
SUBMITTER: Cochrane SW
PROVIDER: S-EPMC2635070 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Blood 20081016 5
Hematopoiesis consists of a series of lineage decisions controlled by specific gene expression that is regulated by transcription factors and intracellular signaling events in response to environmental cues. Here, we demonstrate that the balance between E-protein transcription factors and their inhibitors, Id proteins, is important for the myeloid-versus-lymphoid fate choice. Using Id1-GFP knockin mice, we show that transcription of the Id1 gene begins to be up-regulated at the granulocyte-macro ...[more]