Dissociable roles of cortical excitation-inhibition balance during patch-leaving versus value-guided decisions.

ABSTRACT: In a dynamic world, it is essential to decide when to leave an exploited resource. Such patch-leaving decisions involve balancing the cost of moving against the gain expected from the alternative patch. This contrasts with value-guided decisions that typically involve maximizing reward by selecting the current best option. Patterns of neuronal activity pertaining to patch-leaving decisions have been reported in dorsal anterior cingulate cortex (dACC), whereas competition via mutual inhibition in ventromedial prefrontal cortex (vmPFC) is thought to underlie value-guided choice. Here, we show that the balance between cortical excitation and inhibition (E/I balance), measured by the ratio of GABA and glutamate concentrations, plays a dissociable role for the two kinds of decisions. Patch-leav

SUBMITTER: Kaiser LF 

PROVIDER: S-EPMC7875994 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature