Synthesis and antifungal activity of (-)-(Z)-dysidazirine.
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ABSTRACT:
SUBMITTER: Skepper CK
PROVIDER: S-EPMC2635126 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
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Synthesis and antifungal activity of (-)-(Z)-dysidazirine.
Skepper Colin K CK Dalisay Doralyn S DS Molinski Tadeusz F TF
Organic letters 20081021 22
A short, flexible synthesis of the marine natural product (2 R)-(Z)-dysidazirine (-)-1 has been completed. (-)-1 shows significant antifungal activity across a panel of seven human pathogens, whereas the structural analogue (-)-2, featuring a terminal tert-butyl group, is essentially inactive. ...[more]
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