Unknown

Dataset Information

0

Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids.

ABSTRACT: A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, and their structures were characterized by HRMS, FTIR and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution broth method against five strains of pathogenic fungi. The result indicated that the target compounds exhibited moderate to satisfactory activity. Furthermore, molecular docking was performed to investigate the binding affinities and interaction modes between the target compound and N-myristoyltransferase. Based on the results, preliminary structure activity relationships (SARs) were summarized to serve as a foundation for further investigation.

SUBMITTER: Liang Z 

PROVIDER: S-EPMC6274255 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids.

Liang Zhen Z   Xu Hang H   Tian Ye Y   Guo Mengbi M   Su Xin X   Guo Chun C  

Molecules (Basel, Switzerland) 20160607 6

A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, and their structures were characterized by HRMS, FTIR and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution broth method against five strains of pathogenic fungi. The result indicated that the target compounds exhibited moderate to satisfactory activity. Furthermore, molecular docking was performed to investigate the binding affinities and interaction modes  ...[more]

Similar Datasets

Unknown Design, Synthesis, and Antifungal Activity of Novel Aryl-1,2,3-Triazole-?-Carboline Hybrids.
| S-EPMC6100246 | biostudies-literature
Unknown Novel Triazole Hybrids of Betulin: Synthesis and Biological Activity Profile.
| S-EPMC6150379 | biostudies-literature
Unknown Design, Synthesis, and Biological Activity of New Triazole and Nitro-Triazole Derivatives as Antifungal Agents.
| S-EPMC6152269 | biostudies-literature
Unknown Synthesis and antifungal activity of novel triazole compounds containing piperazine moiety.
| S-EPMC6271785 | biostudies-literature
Unknown Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease.
| S-EPMC7397262 | biostudies-literature
Unknown Design, Synthesis and Antibacterial Activity of Coumarin-1,2,3-triazole Hybrids Obtained from Natural Furocoumarin Peucedanin.
| S-EPMC6600338 | biostudies-literature
Unknown Synthesis and Antifungal Activity of Novel Myrtenal-Based 4-Methyl-1,2,4-triazole-thioethers.
| S-EPMC6155697 | biostudies-literature
Unknown Synthesis, antifungal and antibacterial activity for novel amide derivatives containing a triazole moiety.
| S-EPMC3598687 | biostudies-literature
Unknown Synthesis and antifungal activity of novel oxazolidin-2-one-linked 1,2,3-triazole derivatives.
| S-EPMC6072431 | biostudies-literature
Unknown Design, Synthesis, and Antifungal Activity of Novel Longifolene-Derived Diacylhydrazine Compounds.
| S-EPMC8028131 | biostudies-literature