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Structure of the thioredoxin-fold domain of human phosducin-like protein 2.

ABSTRACT: Human phosducin-like protein 2 (hPDCL2) has been identified as belonging to subgroup II of the phosducin (Pdc) family. The members of this family share an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. The X-ray crystal structure of the Trx-fold domain of hPDCL2 was solved at 2.70 A resolution and resembled the Trx-fold domain of rat phosducin. Comparative structural analysis revealed the structural basis of their putative functional divergence.

SUBMITTER: Lou X

PROVIDER: S-EPMC2635858 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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Structure of the thioredoxin-fold domain of human phosducin-like protein 2.

Lou Xiaochu X Bao Rui R Zhou Cong Zhao CZ Chen Yuxing Y

Acta crystallographica. Section F, Structural biology and crystallization communications 20090131 Pt 2

Human phosducin-like protein 2 (hPDCL2) has been identified as belonging to subgroup II of the phosducin (Pdc) family. The members of this family share an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. The X-ray crystal structure of the Trx-fold domain of hPDCL2 was solved at 2.70 A resolution and resembled the Trx-fold domain of rat phosducin. Comparative structural analysis revealed the structural basis of their putative functional divergence. ...[more]

PMID: 19193988

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