Ontology highlight
ABSTRACT:
SUBMITTER: Hsu CH
PROVIDER: S-EPMC3527542 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Hsu Chun-Hua CH Shen Tang-Long TL Chang Chi-Fon CF Chang Yu-Yung YY Huang Lin-Ya LY
PloS one 20121220 12
The novel tumor biomarker MIEN1, identified by representational difference analysis, is overexpressed in breast cancer and prostate cancer. MIEN1 is considered an oncogenic protein, because MIEN1 overexpression functionally enhances migration and invasion of tumor cells via modulating the activity of AKT. However, the structure and molecular function of MIEN1 is little understood. Here, we report the solution structure of MIEN1, which adopts a thioredoxin-like fold with a redox-active motif. Com ...[more]