Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC2636689 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Li Ya Y Chase Anna R AR Slivka Peter F PF Baggett Clyde T CT Zhao Tina X TX Yin Hang H
Bioconjugate chemistry 20081201 12
A generally applicable strategy of chemically labeling (-)-morphine (1) is described. The synthesis starts from commercially available starting materials and can be completed in two steps with an overall yield of 23%. In silico simulation and NMR results show that the binding of (-)-morphine to one of its molecular targets, toll-like receptor 4 (TLR4), was not affected by the modification. Secreted embryonic alkaline phosphatase (SEAP) reporter assay results demonstrate that C(3) biotinylated an ...[more]