Ontology highlight
ABSTRACT:
SUBMITTER: Park JT
PROVIDER: S-EPMC2636690 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Park Joon T JT Shih Ie-Ming IeM Wang Tian-Li TL
Cancer research 20081101 21
Notch3 gene amplification has recently been identified in ovarian cancer but the Notch3 effectors that are involved in the development of ovarian cancer remain elusive. In this study, we have identified Pbx1, a proto-oncogene in hematopoietic malignancy, as a Notch3 target gene. Pbx1 expression is transcriptionally regulated by Notch3 activation, and Notch3/CSL protein complex directly binds to the Pbx1 promoter segment harboring the CSL-binding sequence. The growth-inhibitory effect of gamma-se ...[more]