Notch3 pathway alterations in ovarian cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Hu W
PROVIDER: S-EPMC4058356 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Notch3 pathway alterations in ovarian cancer.
Hu Wei W Liu Tao T Ivan Cristina C Sun Yunjie Y Huang Jie J Mangala Lingegowda S LS Miyake Takahito T Dalton Heather J HJ Pradeep Sunila S Rupaimoole Rajesh R Previs Rebecca A RA Han Hee Dong HD Bottsford-Miller Justin J Zand Behrouz B Kang Yu Y Pecot Chad V CV Nick Alpa M AM Wu Sherry Y SY Lee Ju-Seog JS Sehgal Vasudha V Ram Prahlad P Liu Jinsong J Tucker Susan L SL Lopez-Berestein Gabriel G Baggerly Keith A KA Coleman Robert L RL Sood Anil K AK
Cancer research 20140417 12
The Notch pathway plays an important role in the growth of high-grade serous ovarian (HGS-OvCa) and other cancers, but its clinical and biologic mechanisms are not well understood. Here, we found that the Notch pathway alterations are prevalent and significantly related to poor clinical outcome in patients with ovarian cancer. Particularly, Notch3 alterations, including amplification and upregulation, were highly associated with poor patient survival. Targeting Notch3 inhibited ovarian cancer gr ...[more]
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