Ontology highlight
ABSTRACT:
SUBMITTER: Chen M
PROVIDER: S-EPMC2636704 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Chen Mo M Zhu Mei M Awad Hani H Li Tian-Fang TF Sheu Tzong-Jen TJ Boyce Brendan F BF Chen Di D O'Keefe Regis J RJ
Journal of cell science 20080408 Pt 9
The Wnt/beta-catenin signaling pathway is essential for normal skeletal development because conditional gain or loss of function of beta-catenin in cartilage results in embryonic or early postnatal death. To address the role of beta-catenin in postnatal skeletal growth and development, Col2a1-ICAT transgenic mice were generated. Mice were viable and had normal size at birth, but became progressively runted. Transgene expression was limited to the chondrocytes in the growth plate and articular ca ...[more]