Ontology highlight
ABSTRACT:
SUBMITTER: Stocker AM
PROVIDER: S-EPMC2674140 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Stocker Adam M AM Chenn Anjen A
Developmental biology 20090114 1
Cerebral cortical precursor cells reside in a neuroepithelial cell layer that regulates their proliferation and differentiation. Global disruptions in epithelial architecture induced by loss of the adherens junction component alphaE-catenin lead to hyperproliferation. Here we show that cell autonomous reduction of alphaE-catenin in the background of normal precursors in vivo causes cells to prematurely exit the cell cycle, differentiate into neurons, and migrate to the cortical plate, while norm ...[more]