Ontology highlight
ABSTRACT:
SUBMITTER: Hogan MC
PROVIDER: S-EPMC2637052 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Hogan Marie C MC Manganelli Luca L Woollard John R JR Masyuk Anatoliy I AI Masyuk Tatyana V TV Tammachote Rachaneekorn R Huang Bing Q BQ Leontovich Alexey A AA Beito Thomas G TG Madden Benjamin J BJ Charlesworth M Cristine MC Torres Vicente E VE LaRusso Nicholas F NF Harris Peter C PC Ward Christopher J CJ
Journal of the American Society of Nephrology : JASN 20090121 2
Proteins associated with autosomal dominant and autosomal recessive polycystic kidney disease (polycystin-1, polycystin-2, and fibrocystin) localize to various subcellular compartments, but their functional site is thought to be on primary cilia. PC1+ vesicles surround cilia in Pkhd1(del2/del2) mice, which led us to analyze these structures in detail. We subfractionated urinary exosome-like vesicles (ELVs) and isolated a subpopulation abundant in polycystin-1, fibrocystin (in their cleaved forms ...[more]