Ontology highlight
ABSTRACT:
SUBMITTER: Shtengel G
PROVIDER: S-EPMC2637278 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Shtengel Gleb G Galbraith James A JA Galbraith Catherine G CG Lippincott-Schwartz Jennifer J Gillette Jennifer M JM Manley Suliana S Sougrat Rachid R Waterman Clare M CM Kanchanawong Pakorn P Davidson Michael W MW Fetter Richard D RD Hess Harald F HF
Proceedings of the National Academy of Sciences of the United States of America 20090206 9
Understanding molecular-scale architecture of cells requires determination of 3D locations of specific proteins with accuracy matching their nanometer-length scale. Existing electron and light microscopy techniques are limited either in molecular specificity or resolution. Here, we introduce interferometric photoactivated localization microscopy (iPALM), the combination of photoactivated localization microscopy with single-photon, simultaneous multiphase interferometry that provides sub-20-nm 3D ...[more]