Ontology highlight
ABSTRACT:
SUBMITTER: Pincheira R
PROVIDER: S-EPMC2637331 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Pincheira Roxana R Baerwald Melinda M Dunbar James D JD Donner David B DB
The EMBO journal 20090108 3
By screening a fetal brain two-hybrid library with the death domain of the p75 neurotrophin receptor (NTR), we identified the Sall2 transcription factor as a novel interacting protein. Sall2 is a unique member of the Sall gene family, which is believed to be a tumour suppressor. Here, we show that Sall2 contains a p75NTR interaction domain not found in other Sall proteins and that p75NTR/Sall2 complexes co-immunoprecipitate from brain lysates. NGF dissociates p75NTR/Sall2 complexes and activates ...[more]