Ontology highlight
ABSTRACT:
SUBMITTER: Blouet C
PROVIDER: S-EPMC2637401 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Blouet Clémence C Ono Hiraku H Schwartz Gary J GJ
Cell metabolism 20081201 6
p70 S6 kinase 1 (S6K) is a major downstream effector of the mammalian target of rapamycin (mTOR), primarily implicated in the control of protein synthesis, cell growth, and proliferation. Here we demonstrate that specific bidirectional molecular targeting of mediobasal hypothalamic (MBH) S6K activity in rats is sufficient to significantly alter food intake, body weight, hypothalamic orexigenic neuropeptide expression, hypothalamic leptin sensitivity, and the metabolic and feeding responses to a ...[more]