DNA structure-induced genomic instability in vivo.
Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC2639325 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
DNA structure-induced genomic instability in vivo.
Wang Guliang G Carbajal Steve S Vijg Jan J DiGiovanni John J Vasquez Karen M KM
Journal of the National Cancer Institute 20081209 24
Noncanonical DNA structures are postulated to be responsible for some breakpoint hotspots that occur frequently in cancers. We developed a novel mouse model system using the naturally occurring H-DNA structure that deviate from the familiar right-handed helical B form found at the breakage hotspot in the human c-MYC promoter and a Z-DNA-forming CG repeat to test this idea directly. Large-scale chromosomal deletions and/or translocations occurred in 5 (7.7%, 95% confidence interval [CI] = 3.7% to ...[more]
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