Ontology highlight
ABSTRACT:
SUBMITTER: Savage KI
PROVIDER: S-EPMC4024319 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Savage Kienan I KI Matchett Kyle B KB Barros Eliana M EM Cooper Kevin M KM Irwin Gareth W GW Gorski Julia J JJ Orr Katy S KS Vohhodina Jekaterina J Kavanagh Joy N JN Madden Angelina F AF Powell Alexander A Manti Lorenzo L McDade Simon S SS Park Ben Ho BH Prise Kevin M KM McIntosh Stuart A SA Salto-Tellez Manuel M Richard Derek J DJ Elliott Christopher T CT Harkin D Paul DP
Cancer research 20140317 10
Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through critical roles in DNA repair, cell-cycle arrest, and transcriptional control. A major question has been why BRCA1 loss or mutation leads to tumors mainly in estrogen-regulated tissues, given that BRCA1 has essential functions in all cell types. Here, we report that estrogen and estrogen metabolites can cause DNA double-strand breaks (DSB) in est ...[more]