Ontology highlight
ABSTRACT:
SUBMITTER: Lin CH
PROVIDER: S-EPMC2642969 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Lin Chia-Hui CH Li Bing B Swanson Selene S Zhang Ying Y Florens Laurence L Washburn Michael P MP Abmayr Susan M SM Workman Jerry L JL
Molecular cell 20081201 5
Recent discoveries of histone demethylases demonstrate that histone methylation is reversible. However, mechanisms governing the targeting and regulation of histone demethylation remain elusive. Here we report that a Drosophila melanogaster JmjC domain-containing protein, dKDM4A, is a histone H3K36 demethylase. dKDM4A specifically demethylates H3K36me2 and H3K36me3 both in vitro and in vivo. Affinity purification and mass spectrometry analysis revealed that heterochromatin protein 1a (HP1a) asso ...[more]