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Design and synthesis of vidarabine prodrugs as antiviral agents.

ABSTRACT: 5'-O-D- and L-amino acid derivatives and 5'-O-(D- and L-amino acid methyl ester phosphoramidate) derivatives of vidarabine (ara-A) were synthesized as vidarabine prodrugs. Some compounds were equi- or more potent in vitro than vidarabine against two pox viruses and their uptake by cultured cells was improved compared to the parent drug.

SUBMITTER: Shen W

PROVIDER: S-EPMC2642980 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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Design and synthesis of vidarabine prodrugs as antiviral agents.

Shen Wei W Kim Jae-Seung JS Kish Phillip E PE Zhang Jie J Mitchell Stefanie S Gentry Brian G BG Breitenbach Julie M JM Drach John C JC Hilfinger John J

Bioorganic & medicinal chemistry letters 20081210 3

5'-O-D- and L-amino acid derivatives and 5'-O-(D- and L-amino acid methyl ester phosphoramidate) derivatives of vidarabine (ara-A) were synthesized as vidarabine prodrugs. Some compounds were equi- or more potent in vitro than vidarabine against two pox viruses and their uptake by cultured cells was improved compared to the parent drug. ...[more]

PMID: 19097789

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