Ontology highlight
ABSTRACT:
SUBMITTER: Singh SB
PROVIDER: S-EPMC4027230 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Singh Sheo B SB Rindgen Diane D Bradley Prudence P Cama Lovji L Sun Wanying W Hafey Michael J MJ Suzuki Takao T Wang Nengxue N Wu Hao H Zhang Basheng B Wang Li L Ji Chongmin C Yu Hongshi H Soll Richard R Olsen David B DB Meinke Peter T PT Nicoll-Griffith Deborah A DA
ACS medicinal chemistry letters 20130703 8
Carbapenems are intravenous lifesaving hospital antibiotics. Once patients leave the hospital, they are sent home with antibiotics other than carbapenems since they cannot be administered orally due to lack of oral absorption primarily because of very highly polarity. A prodrug approach is a bona fide strategy to improve oral absorption of compounds. Design and synthesis, in vitro and in vivo evaluation of diversified prodrugs of ertapenem, one of the only once daily dosed carbapenems is describ ...[more]