Ontology highlight
ABSTRACT:
SUBMITTER: Nobrega-Pereira S
PROVIDER: S-EPMC2643060 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Nóbrega-Pereira Sandrina S Kessaris Nicoletta N Du Tonggong T Kimura Shioko S Anderson Stewart A SA Marín Oscar O
Neuron 20080901 5
The homeodomain transcription factor Nkx2-1 plays key roles in the developing telencephalon, where it regulates the identity of progenitor cells in the medial ganglionic eminence (MGE) and mediates the specification of several classes of GABAergic and cholinergic neurons. Here, we have investigated the postmitotic function of Nkx2-1 in the migration of interneurons originating in the MGE. Experimental manipulations and mouse genetics show that downregulation of Nkx2-1 expression in postmitotic c ...[more]