Ontology highlight
ABSTRACT:
SUBMITTER: Persson CM
PROVIDER: S-EPMC2643636 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Persson Catrine M CM Lambert Henrik H Vutova Polya P PP Dellacasa-Lindberg Isabel I Nederby Joanna J Yagita Hideo H Ljunggren Hans-Gustaf HG Grandien Alf A Barragan Antonio A Chambers Benedict J BJ
Infection and immunity 20090112 3
The obligate intracellular parasite Toxoplasma gondii can actively infect any nucleated cell type, including cells from the immune system. In the present study, we observed that a large number of natural killer (NK) cells were infected by T. gondii early after intraperitoneal inoculation of parasites into C57BL/6 mice. Interestingly, one mechanism of NK cell infection involved NK cell-mediated targeting of infected dendritic cells (DC). Perforin-dependent killing of infected DC led to active egr ...[more]