Ontology highlight
ABSTRACT:
SUBMITTER: Frappart PO
PROVIDER: S-EPMC2644132 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Frappart Pierre-Olivier PO Lee Youngsoo Y Russell Helen R HR Chalhoub Nader N Wang Yong-Dong YD Orii Kenji E KE Zhao Jingfeng J Kondo Naomi N Baker Suzanne J SJ McKinnon Peter J PJ
Proceedings of the National Academy of Sciences of the United States of America 20090121 6
Inactivation of homologous recombination (HR) or nonhomologous end-joining (NHEJ) predisposes to a spectrum of tumor types. Here, we inactivated DNA double-strand break repair (DSBR) proteins, DNA Ligase IV (Lig4), Xrcc2, and Brca2, or combined Lig4/Xrcc2 during neural development using Nestin-cre. In all cases, inactivation of these repair factors, together with p53 loss, led to rapid medulloblastoma formation. Genomic analysis of these tumors showed recurring chromosome 13 alterations via chro ...[more]