Ontology highlight
ABSTRACT:
SUBMITTER: Hromas R
PROVIDER: S-EPMC2644637 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Hromas Robert R Wray Justin J Lee Suk-Hee SH Martinez Leah L Farrington Jacqueline J Corwin Lori Kwan LK Ramsey Heather H Nickoloff Jac A JA Williamson Elizabeth A EA
DNA repair 20080918 12
Transposase domain proteins mediate DNA movement from one location in the genome to another in lower organisms. However, in human cells such DNA mobility would be deleterious, and therefore the vast majority of transposase-related sequences in humans are pseudogenes. We recently isolated and characterized a SET and transposase domain protein termed Metnase that promotes DNA double-strand break (DSB) repair by non-homologous end-joining (NHEJ). Both the SET and transposase domain were required fo ...[more]