Ontology highlight
ABSTRACT:
SUBMITTER: Adio S
PROVIDER: S-EPMC2644789 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Adio Sarah S Jaud Johann J Ebbing Bettina B Rief Matthias M Woehlke Günther G
PloS one 20090226 2
The protein family of kinesins contains processive motor proteins that move stepwise along microtubules. This mechanism requires the precise coupling of the catalytic steps in the two heads, and their precise mechanical coordination. Here we show that these functionalities can be uncoupled in chimera of processive and non-processive kinesins. A chimera with the motor domain of Kinesin-1 and the dimerization domain of a non-processive Kinesin-3 motor behaves qualitatively as conventional kinesin ...[more]