Ontology highlight
ABSTRACT:
SUBMITTER: Jin Y
PROVIDER: S-EPMC6816667 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Jin Yumei Y Geng Yizhao Y Lü Lina L Ma Yilong Y Lü Gang G Zhang Hui H Ji Qing Q
Cellular and molecular bioengineering 20170215 2
Microtubule not only provides the track for kinesin but also modulates kinesin's mechanochemical cycle. Microtubule binding greatly increases the rates of two chemical steps occurring inside the nucleotide-binding pocket (NBP) of kinesin, i.e., ATP hydrolysis and ADP release. Kinesin neck linker docking (the key force-generation step) is initiated by the motor head rotation induced by ATP binding which needs an anchor provided by microtubule. These functions of microtubule can only be accomplish ...[more]