Unusual codon usage bias in low expression genes of Vibrio cholerae.
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ABSTRACT:
SUBMITTER: Basak S
PROVIDER: S-EPMC2646191 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
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Unusual codon usage bias in low expression genes of Vibrio cholerae.
Basak Surajit S Mukherjee Indranuj I Choudhury Mayukh M Das Santasabuj S
Bioinformation 20081231 5
Positive correlation between gene expression and synonymous codon usage bias is well documented in the literature. However, in the present study of Vibrio cholerae genome, we have identified a group of genes having unusually high codon usage bias despite being low potential expressivity. Our results suggest that codon usage in lowly expressed genes might also be selected on to preferably use non-optimal codons to maintain a low cellular concentration of the proteins that they encode. This would ...[more]
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