Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC2646284 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Liu Zhandong Z Wang Min M Alvarez James V JV Bonney Megan E ME Chen Chien-chung CC D'Cruz Celina C Pan Tien-chi TC Tadesse Mahlet G MG Chodosh Lewis A LA
Genome biology 20081218 12
The ability to detect activation of signaling pathways based solely on gene expression data represents an important goal in biological research. We tested the sensitivity of singular value decomposition-based regression by focusing on functional interactions between the Ras and transforming growth factor beta signaling pathways. Our findings demonstrate that this approach is sufficiently sensitive to detect the secondary activation of endogenous signaling pathways as it occurs through crosstalk ...[more]