Ontology highlight
ABSTRACT:
SUBMITTER: Dudkin VY
PROVIDER: S-EPMC2646745 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20080918 41
Prostate specific antigen (PSA) molecules secreted by cancerous and normal prostate cells differ in their N-linked glycan composition, while the peptide backbone appears to be conserved. Antibodies selectively recognizing such differentially glycosylated PSA structures could form a basis for a new diagnostic assay for prostate cancer. Twenty-amino acid PSA fragments carrying di-, tri-, and tetrabranched complex-type glycans were prepared by total synthesis and conjugated to maleimide-modified ke ...[more]