Ontology highlight
ABSTRACT:
SUBMITTER: Akagi T
PROVIDER: S-EPMC2647673 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Akagi Tadayuki T Shih Lee-Yung LY Kato Motohiro M Kawamata Norihiko N Yamamoto Go G Sanada Masashi M Okamoto Ryoko R Miller Carl W CW Liang Der-Cherng DC Ogawa Seishi S Koeffler H Phillip HP
Blood 20081223 8
Acute promyelocytic leukemia (APL) is a hematopoietic malignant disease characterized by the chromosomal translocation t(15;17), resulting in the formation of the PML-RARA gene. Here, 47 t(15;17) APL samples were analyzed with high-density single-nucleotide polymorphism microarray (50-K and 250-K SNP-chips) using the new algorithm AsCNAR (allele-specific copy-number analysis using anonymous references). Copy-number-neutral loss of heterozygosity (CNN-LOH) was identified at chromosomes 10q (3 cas ...[more]