Ontology highlight
ABSTRACT:
SUBMITTER: Gereben B
PROVIDER: S-EPMC2647704 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Gereben Balázs B Zavacki Ann Marie AM Ribich Scott S Kim Brian W BW Huang Stephen A SA Simonides Warner S WS Zeöld Anikó A Bianco Antonio C AC
Endocrine reviews 20080924 7
The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore are critical for the biological effects mediated by thyroid hormone. Over the years, research has focused on their role in preserving serum levels of the biologically active molecule T(3) during iodine deficiency. More recently, a fascinating new role of these enzymes has been unveiled. The activating deiodinase (D2) and the inactivating deiodinase (D3) can locally increase or decrease thyroid hormone signal ...[more]