Ontology highlight
ABSTRACT:
SUBMITTER: Ueta CB
PROVIDER: S-EPMC3355550 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Ueta Cintia B CB Oskouei Behzad N BN Olivares Emerson L EL Pinto Jose R JR Correa Mayrin M MM Simovic Gordana G Simonides Warner S WS Hare Joshua M JM Bianco Antonio C AC
Molecular endocrinology (Baltimore, Md.) 20120308 5
Cardiac injury induces myocardial expression of the thyroid hormone inactivating type 3 deiodinase (D3), which in turn dampens local thyroid hormone signaling. Here, we show that the D3 gene (Dio3) is a tissue-specific imprinted gene in the heart, and thus, heterozygous D3 knockout (HtzD3KO) mice constitute a model of cardiac D3 inactivation in an otherwise systemically euthyroid animal. HtzD3KO newborns have normal hearts but later develop restrictive cardiomyopathy due to cardiac-specific incr ...[more]