Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1.
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ABSTRACT:
SUBMITTER: Huberman AD
PROVIDER: S-EPMC2647846 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Publications
Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1.
Huberman Andrew D AD Speer Colenso M CM Chapman Barbara B
Neuron 20061001 2
The mechanisms that give rise to ocular dominance columns (ODCs) during development are controversial. Early experiments indicated a key role for retinal activity in ODC formation. However, later studies showed that in those early experiments, the retinal activity perturbation was initiated after ODCs had already formed. Moreover, recent studies concluded that early eye removals do not impact ODC segregation. Here we blocked spontaneous retinal activity during the very early stages of ODC develo ...[more]
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