Ontology highlight
ABSTRACT:
SUBMITTER: Bisbal M
PROVIDER: S-EPMC2648138 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Bisbal Mariano M Conde Cecilia C Donoso Maribel M Bollati Flavia F Sesma Juliana J Quiroga Santiago S Díaz Añel Alberto A Malhotra Vivek V Marzolo Maria Paz MP Cáceres Alfredo A
The Journal of neuroscience : the official journal of the Society for Neuroscience 20080901 37
In non-neuronal cells, inactivation of protein kinase D (PKD) blocks fission of trans-Golgi network (TGN) transport carriers, inducing the appearance of long tubules filled with cargo. We now report on the function of PKD1 in neuronal protein trafficking. In cultured hippocampal pyramidal cells, the transferrin receptor (TfR) and the low-density receptor-related protein (LRP) are predominantly transported to dendrites and excluded from axons. Expression of kinase-inactive PKD1 or its depletion b ...[more]