Ontology highlight
ABSTRACT:
SUBMITTER: Katoh T
PROVIDER: S-EPMC2648654 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Katoh Takayuki T Sakaguchi Yuriko Y Miyauchi Kenjyo K Suzuki Takeo T Kashiwabara Shin-Ichi S Baba Tadashi T Suzuki Tsutomu T
Genes & development 20090201 4
The steady-state levels of microRNAs (miRNAs) and their activities are regulated by the post-transcriptional processes. It is known that 3' ends of several miRNAs undergo post-dicing adenylation or uridylation. We isolated the liver-specific miR-122 from human hepatocytes and mouse livers. Direct analysis by mass spectrometry revealed that one variant of miR-122 has a 3'-terminal adenosine that is introduced after processing by Dicer. We identified GLD-2, which is a regulatory cytoplasmic poly(A ...[more]