Ontology highlight
ABSTRACT:
SUBMITTER: Nakel K
PROVIDER: S-EPMC4931106 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Nakel Katharina K Bonneau Fabien F Basquin Claire C Habermann Bianca B Eckmann Christian R CR Conti Elena E
RNA (New York, N.Y.) 20160610 8
Cytoplasmic polyadenylation drives the translational activation of specific mRNAs in early metazoan development and is performed by distinct complexes that share the same catalytic poly(A)-polymerase subunit, GLD-2. The activity and specificity of GLD-2 depend on its binding partners. In Caenorhabditis elegans, GLD-2 promotes spermatogenesis when bound to GLD-3 and oogenesis when bound to RNP-8. GLD-3 and RNP-8 antagonize each other and compete for GLD-2 binding. Following up on our previous mec ...[more]