Ontology highlight
ABSTRACT:
SUBMITTER: Phakthanakanok K
PROVIDER: S-EPMC2648740 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Phakthanakanok Krongsakda K Ratanakhanokchai Khanok K Kyu Khin Lay KL Sompornpisut Pornthep P Watts Aaron A Pinitglang Surapong S
BMC bioinformatics 20090130
<h4>Background</h4>SARS coronavirus main proteinase (SARS CoVMpro) is an important enzyme for the replication of Severe Acute Respiratory Syndrome virus. The active site region of SARS CoVMpro is divided into 8 subsites. Understanding the binding mode of SARS CoVMpro with a specific substrate is useful and contributes to structural-based drug design. The purpose of this research is to investigate the binding mode between the SARS CoVMpro and two octapeptides, especially in the region of the S3 s ...[more]