Variants in TGFB1, dust mite exposure, and disease severity in children with asthma.
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ABSTRACT:
SUBMITTER: Sharma S
PROVIDER: S-EPMC2648908 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
Variants in TGFB1, dust mite exposure, and disease severity in children with asthma.
Sharma Sunita S Raby Benjamin A BA Hunninghake Gary M GM Soto-Quirós Manuel M Avila Lydiana L Murphy Amy J AJ Lasky-Su Jessica J Klanderman Barbara J BJ Sylvia Jody S JS Weiss Scott T ST Celedón Juan C JC
American journal of respiratory and critical care medicine 20081218 5
<h4>Rationale</h4>Polymorphisms in the gene for transforming growth factor-beta1 (TGFB1) have been associated with asthma, but not with airway responsiveness or disease exacerbations in subjects with asthma.<h4>Objectives</h4>To test for association between single nucleotide polymorphisms (SNPs) in TGFB1 and markers of asthma severity in childhood.<h4>Methods</h4>We tested for the association between nine SNPs in TGFB1 and indicators of asthma severity (lung function, airway responsiveness, and ...[more]
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